Semaglutide (GLP-1) Updates for Obesity, Nash, and Diabetes

Tirzepatide: The New Kid On The Block

It’s not really a new kid on the block, but rather a new FDA indication.  Just as Ozempic (marketed for type 2 diabetes)  and Wegovy (marketed for weight loss)  are identical semaglutide drugs we now have Mounjaro (marketed for type 2 diabetes) and Zepbound (marketed for weight loss) as identical twins.  The recent SURMOUNT-3 phase 3 trial for “tirzepatide after intensive lifestyle intervention in adults overweight or obesity” is summarized below:

  • Tirzepatide led to an additional 21.1% mean weight loss after the lifestyle intervention, for a total mean weight loss of 26.6% from the start of the study over 84 weeks.
  • Tirzepatide was superior to placebo in achieving and maintaining weight reduction of at least 5% or 20%, and in reducing waist circumference and body fat percentage.
  • Tirzepatide also improved blood pressure, cholesterol, liver function, and quality of life measures.
  • Tirzepatide had a similar safety profile to other drugs that activate the GLP-1 and GIP receptors, with the most common side effects being gastrointestinal-related.

The press is now calling Zepbound (poor Mounjaro is almost forgotten) a game changer! Without double, Zepbound not only for weight loss, but also for impressive cardio-vascular benefits. 

 Not to play favorites, I must mention recent data on Wegovy that has also demonstrated a decrease in morbidity and mortality with patients with pre-existing cardiac disease.
So the GLP-1+/-GIP are our current game changing drugs,  just waiting for the next kid on the block (?a once a day pill) to call them out for a head to head challenge.  Can’t wait to see who can draw the fastest.

1,032 thoughts on “Tirzepatide”

  1. Thanks for your marveslous posting! I genuinely
    enjoyed reading it, you can be a great author.I
    will be sure to bookmark your blog and will
    eventually come back at some point. I want to encourage yourself to continue
    your great writing, have a nice morning! https://telegra.ph/Uatronica–Vash-Prov%D1%96dnij-Postachalnik-Elektronnih-Komponent%D1%96v-ta-Rad%D1%96odetalej-dlya-B%D1%96znesu-08-19

  2. Hello there, I found your blog via Google at the same tiime aas
    looking for a similasr topic, your site got here up, it appears to be like good.
    I have bookmarked it iin myy google bookmarks.
    Hi there, just turned into alert to your blog thru Google, and located that it’s really informative.
    I’m gonna be careful for brussels. I will be grateful in case you
    contine this in future. A lot of other folks will be benefited from your
    writing. Cheers! https://odessaforum.biz.ua/

Leave a Reply to https://icelandgamblings.mystrikingly.com/ Cancel Reply

Your email address will not be published. Required fields are marked *