Answers and Discussions
Questions and Answers to Vocabulary 101
Name Five Organs with Semaglutide Receptors.
Endocrine pancreas, central and peripheral nervous systems (brain), gastrointestinal tract (intestines), cardiovascular system (heart), kidney, and lung
Name a drug that is an Opioid receptor blocker.
Naloxone, Naltrexone
What is the BMI for a male 5’10” and weights 280 pounds ? (28/36/40/44)
40
Dividing weight in pounds (lb) by height in inches (in) squared and multiplying by a conversion factor of 703
Can FDA licensed Pharmacists coumpound tirzepatide ?
Recently Eli Lilly lost a court case against a company selling compounded tirzepatide.
Can my doctor prescribe a medication to avoid gastroparesis ?
Some providers are prescribing metoclopramide drugs to combat some of the symptoms of nausea and gastric retention. To date no published study has evaluated this old medication. Please be advised of a Black Box Waring Label on metoclopramide placed by the FDA some years ago.
What drug is undergoing clinical studies of oral high dose to combat the short half life ?
Novo is doing a double blind study on high dose (50 mg) Rybelsus. A current study of an experimental drug with a twice a day oral dose resulted in 50% of those taking the active drug stopped due to GI side effects.
What are the three most serious potential complications of GLP-1RA’s ?
Pancreatitis, Bowel Obstruction, Biliary Track Disease (Gallstones)
What serious acute complication of diabetics on insulin does a shot of glucagon cure?
Hypoglycemia (low blood sugar)
What are the two drugs that are FDA approved that contain two incretins ?
Mounjaro and Zepbound. Mounjaro is FDA approved for Diabetes Type 2. Zepbound is FDA approved for Obesity and Obesity related complications. Of note is that Mounjaro and Zepbound are identical medications.
How many times higher is the risk of bowel obstruction in the JAMA 11/15 2023 study compared to buproprion-naltrexone ? (2, 5, 7, 9)
7
What is the risk of taking insulin with semaglutide meds ?
Hypoglycemia (low blood sugar). For this reason it is contraindicated for insulin dependent type 1 diabetes to take semaglutide.
How many time higher is the risk of pancreatitis in the JAMA 11/15 2023 study compared to buproprion-naltrexone ?
9
